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-Hexosaminidases: Potent Mitogens of Airway Smooth Muscle

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Abstract:

-Hexosaminidases A & B, inflammatory marker enzymes, are mannosyl-rich glycoproteins that are implicated in acute asthma. At physiologically and pathologically relevant concentrations (nM), -Hexosaminidases act as potent mitogens of bovine airway smooth muscle cells. This mitogenic action is mediated via 175 kD mannose recognizing receptors that have been isolated from bovine airway smooth muscle cells and human bronchial smooth muscle. There seems to be an involvement of multiple signal transduction pathways in this process and this mitogenic effect is cell density dependent. Moreover, -Hexosaminidases are protease resistant. Thus, -Hexosaminidases may serve as key inflammatory mediators critical to airway remodeling process.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854198778612654

Publication date: 1998-11-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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