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Nitric Oxide in Allergic Rhinitis and Asthma

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Nitric oxide is a free radical molecule that can have both homeostatic and proinflammatory roles in the nasal mucosa, sinuses and airway. We have demonstrated elevated levels of nitric oxide in either nasal fluid, serum and spontaneous, or antigen-stimulated mononuclear cells from patients with allergic rhinitis, sinusitis, and asthma. We also showed that various therapeutic agents such as glucocorticoids, theophylline and macrolides can decrease nitric oxide levels in these patients. Thus determination of nasal, serum, mononuclear cell or airway production of nitric oxide may be an important biomarker of inflammation for monitoring newer anti-inflammatory therapy.

Document Type: Research Article


Publication date: 1998-11-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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