Skip to main content

Immunologic Aspects of Isocyanate Asthma: IL-1, IL-3, IL-4, sIL2R, and sICAM-1

Buy Article:

$31.50 plus tax (Refund Policy)

This pilot study investigated serum levels of cytokines and soluble receptors during five positive and five negative isocyanate inhalational challenges. Serum was obtained from 10 individuals with symptoms compatible with isocyanate asthma before isocyanate challenge and the day following their maximal change in pulmonary function after isocyanate challenge. Serum levels of interleukin 1, interleukin 3, interleukin 4, soluble interleukin 2 receptor, and soluble intercellular adhesion molecule 1 were measured and compared. Interleukin 1, interleukin 3, and interleukin 4 were not detected. The mean soluble interleukin 2 receptor and soluble intercellular adhesion molecule 1 levels were not statistically different before and after challenge or between groups. In summary, the cytokines studied are not detectable in peripheral blood during isocyanate inhalation challenge; soluble interleukin 2 receptor and soluble intercellular adhesion molecule 1 are both detectable but do not change significantly after a positive isocyanate challenge.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Data/Media
No Metrics

Document Type: Research Article

Publication date: 1998-09-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more