Occupational Asthma Caused by FD&C Blue Dye No. 2

Authors: Miller, Maureen E.; Lummus, Zana L.; Bernstein, David I.

Source: Allergy and Asthma Proceedings, Volume 17, Number 1, January-February 1996 , pp. 31-34(4)

Publisher: OceanSide Publications, Inc

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Abstract:

We report the case of a 55-year-old male who experienced cough, dyspnea, wheezing, and nasal congestion immediately upon exposure to FD&C Blue Dye No. 2 (Indigotine) at work. The patient had worked for 10 years mixing and grinding powdered synthetic red, yellow, and blue dyes for use in foods; symptoms had occurred for 2 years and only with exposure to Indigotine (C₁₆H₈N₂Na₂O₈S₂), a free flowing blue powder. Prick testing to Indigoline (20 mg/mL) was negative. ELISA failed to detect specific IgE, IgA, IgM, or IgG to Indigotine-HSA conjugates. Bronchial challenge was done according to the method of Pepys et al. beginning with 4 × 10⁻⁴ lactose dilution of Indigotine powder. After 5 minutes of exposure to 4 gm Indigotine/100 gm lactose, the patient developed dyspnea and audible wheezing. At 20 minutes postexposure, there was a 20% decline in FEV₁ from prechallenge baseline; no late phase response was observed. A second bronchial challenge with sodium sulfate, the major nondye product additive was negative. To our knowledge, this is the first documented case of occupational asthma due to FD&C Blue Dye No. 2. The pathogenesis is uncertain but does not appear to be IgE mediated.

Document Type: Research article

DOI: http://dx.doi.org/10.2500/108854196778662309

Publication date: 1996-01-01

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Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

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Occupational Asthma Caused by FD&C Blue Dye No. 2

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