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The Role of Mast Cells and Basophils in Immunoregulation

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The production of a wide range of cytokines by mast cells in response to activation by allergen places the mast cell in the center of the allergic inflammatory response. These cytokines may lead to eosinophil, basophil, and T cell recruitment. Coordinated production of IL-4 and IL-5 by TH2 helper cells enhanced IgE responsivity, thus perpetuating the allergic inflammatory response. As a variety of leukocytes involved in the allergic inflammatory response may produce cytokines, the critical nature of these mediators of inflammation in promoting and perpetuating inflammation is now well appreciated.

Document Type: Research Article


Publication date: 1996-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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