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The Outcome of Stevens-Johnson Syndrome Treated with Corticosteroids

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Stevens-Johnson Syndrome (SJS) may have considerable morbidity and mortality. Traditional management has been supportive with or without corticosteroids, and we have previously reported our successful experience treating 41 SJS patients with corticosteroids. We now report the outcome of prospectively treating 13 additional patients with SJS with high doses of corticosteroids. Thirteen consecutive patients with SJS were treated with corticosteroids at diagnosis. Their clinical course and outcomes were analyzed. Drug reactions were potential precipitants of SJS in 12 patients. The percent of skin involvement ranged from 30% to 90% with eight patients having greater than 80% involvement. Bullous lesions were seen in two patients. All patients made a complete recovery. Corticosteroid therapy may be lifesaving in these patients; and in our experience, early management of SJS with high dose corticosteroids has been very effective and associated with a full recovery.

Document Type: Research Article


Publication date: July 1, 1995

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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