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Leukotrienes, Fish-Oil, and Asthma

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Studies suggest that leukotrienes which have been metabolized from arachidonic acid released from membranes phospholipids during cell activation may play a significant role in a variety of inflammatory disorders including the pathophysiology of chronic allergic asthma. Two major types of polyunsaturated fatty acids prominent in marine fish oils are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DCHA). These fish oils limit leukotriene synthesis and biological activities by substituting substrate fatty acids as alternatives to arachidonic acid. Both EPA and DCHA inhibit the conversion of arachidonic acid by the cyclooxygenase pathway to prostanoid metabolites and reduce the production of platelet-activating factor (PAF).

Document Type: Research Article


Publication date: 1994-05-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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