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Adenosine and Other Mast Cell Preformed Mediators

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Earlier studies of adenosine as a modulator of mast cell secretory functions have demonstrated that addition of exogenous adenosine to rat peritoneal mast cells has appeared to be a pro-inflammatory molecule in allergic reactions. More recent investigative studies with mouse bone-marrow mast cells have confirmed the role of adenosine as a potent augmenter of mast cell mediator release. Ongoing investigation is centered on characterization of an adenosine subtype in mast cells and biochemical mechanisms by which adenosine may effect bronchoconstrictor response in allergen-sensitive individuals.

Document Type: Research Article


Publication date: May 1, 1994

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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