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Lettuce and Carrot Allergy: Are They Related?

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Lettuce is commonly included in many elimination diets of subjects with either food allergy or atopic dermatitis since IgE-mediated allergic reactions have not been reported. We have observed a positive carrot skin test and/or RAST in two clinically lettuce sensitive, ragweed allergic subjects and positive lettuce skin test and/or RAST in two ragweed allergic patients with oral allergy syndrome to carrot. In this study lettuce allergy and the allergenic relationship between iceberg lettuce (Lactuca sativa L.), a member of the Asteraceae and carrot, a member of the Apiaceae, were investigated using sera from those four individuals. SDS-PAGE immunoblotting results indicated that iceberg lettuce can induce an IgE-mediated response. Fourteen allergens were detected between 13 and >113 kD. RAST inhibition demonstrated that carrot does share common allergens with lettuce, although carrot allergens are more potent than those of lettuce. These findings may have some importance in patients with food-related symptoms, such as atopic dermatitis, because lettuce, when included in their diets, may aggravate the underlying disease.

Document Type: Research Article


Publication date: January 1, 1994

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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