Regulation of IgE Synthesis

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Abstract:

The role of IgE in allergic disease is by now well recognized. The study of the cellular basis of IgE regulation has been actively pursued to gain insights into the pathogenesis of a disease that affects a considerable proportion of the population. More recently, the molecular events underlying IgE synthesis have become the focus of intense interest, in an attempt to characterize the signals involved in isotype-specific regulation of immunoglobulin synthesis. Recent evidence from different laboratories indicates that induction of IgE synthesis requires two signals: one is IgE isotype-specific, and is delivered by IL-4, the other is a B cell activating signal that can be delivered through a variety of pathways. We will herein review what is currently known about the mechanisms underlying the synthesis of IgE in humans, as they are revealed through cellular and molecular biology studies.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854193778792795

Publication date: November 1, 1993

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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