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Malignant Potentially Fatal Asthma: Achievement of Remission and the Application of an Asthma Severity Index

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Patients fulfilling diagnostic criteria for malignant potentially fatal asthma require aggressive involvement by the physician to prevent avoidable fatalities from asthma. Efforts to overcome barriers to treatment caused by noncompliance are critical to successful care. This report reviews five patients with malignant potentially fatal asthma in remission, in whom noncompliance played the major role in preventing control of asthma.

Through patient confrontation and the monitoring of serum concentrations of prednisone and its metabolite prednisolone, noncompliance may be addressed. Psychiatric referral may also be of benefit, if accepted by the patient and family. Use of injectable methylprednisolone may be a necessary alternative to prevent life-threatening complications of asthma. In all patients, keeping medical regimens as simple as possible is advocated, with the use of the lowest doses of medication necessary to maintain the control of symptoms, and the prevention of morbidity and mortality. An asthma severity index for the illustration of longitudinal disease severity is applied to these patients.
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Document Type: Research Article

Publication date: 1993-09-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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