Murine Monoclonal Antibodies to Glycoprotein Antigens of Aspergillus fumigatus show Cross-reactivity with other Fungi

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Abstract:

Six monoclonal antibodies produced against Aspergillus fumigatus were studied for their cross-reactivity against other fungal antigens from related and unrelated organisms. Five of the monoclonal antibodies reacted with glycoprotein antigens as evidenced by their binding to concanavalin A, although one did not react with concanavalin A. The reactivities of the monoclonal antibodies with various antigens were studied by biotin-avidin linked immunosorbent assay and Western blots. The results indicate that two monoclonal antibodies (Asp D1 and Asp C9) react with antigens from aspergilli as well as other fungi including Penicillium notatum and Candida albicans, whereas three of six antibodies (Asp H10, Asp ILB8, and Asp C2B1) react with A. fumigatus antigen only. Hence, these monoclonal antibodies can be used to obtain group specific and species specific antigens for various immunodiagnostic assays.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854193778878664

Publication date: May 1, 1993

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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