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Mechanisms of Inflammation in the Asthmatic Patient

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Our concept of asthma has changed dramatically in the past decade. Although many factors contribute to airflow obstruction in asthma, there is now an expanded focus on all events in bronchial obstruction including bronchospasm, edema, mucous formation, and inflammation. The last of these airway changes, bronchial inflammation, not only causes symptoms of asthma but also contributes or is the cause of a basic characteristic of asthma: airway hyperresponsiveness. It has become apparent that asthma is a complex disease in which the causes of airflow obstruction are multi-factorial, multicellular, and redundant. It is important to identify the cellular mechanisms involved in airway inflammation and to understand how they contribute to changes in airway responsiveness and obstruction.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854193778816752

Publication date: January 1, 1993

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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