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Cytokines: Clinical Potentials for the Allergic Patient

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Abstract:

Classic allergic responses occur as a result of mast cell-bound IgE being cross linked by allergen, causing degranulation and activation with release of multiple biologically active mediators. Such mediators may have a direct effects on target tissues and/or promote the inflammatory milieu typical of late-phase responses. The production of IgE is a normal T-cell dependent antibody response. It is the specificity for allergens that is aberrant, resulting in a hypersensitivity state. Recent work has demonstrated that small molecular weight substances called cytokines are responsible for many immunological activities such as IgE production, mast cell and eosinophil maturation, and proinflammatory mediators that directly contribute to the pathology of late-phase allergic responses. Differences are being sought in the relative production of various cytokines that can be correlated with disease activity. This should find clinical use in diagnosis, prognosis, and/or monitoring of specific immunotherapy. Additionally, therapeutic agents are being sought that have various agonist/antagonist properties to correct aberrant cytokine production. Such agents likely will have a central role in future therapy for allergic diseases.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854192778816979

Publication date: November 1, 1992

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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