@article {Davidson:1992:1088-5412:81,
title = "Delayed Nasal Mucociliary Clearance in Patients with Nonallergic Rhinitis and Nasal Eosinophilia",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "1992",
volume = "13",
number = "2",
publication date ="1992-03-01T00:00:00",
pages = "81-84",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/1992/00000013/00000002/art00006",
doi = "doi:10.2500/108854192778878854",
author = "Davidson, Andrew E. and Miller, S. David and Settipane, Robert J. and Ricci, Anthony R. and Klein, Donald E. and Settipane, Guy A.",
abstract = "This study investigated nasal mucociliary clearance as related to nasal eosinophilia in nonallergic rhinitis patients using the technique of nasal saccharine challenge. Fifty-six consecutive patients with nonallergic rhinitis were evaluated with nasal cytology and saccharine challenge. A saccharine challenge time of greater than 25 minutes was considered abnormal. Twelve of 56 patients (21.4%) had nasal eosinophilia. Fifteen of 56 patients (26.8%) had prolonged nasal circulation times greater than 25 minutes, indicating delayed mucociliary clearance. Although 7 of 12 patients (58.3%) with nasal eosinophilia had delayed mucociliary clearance, only 8 of 44 patients (18.2%) without eosinophilia had circulation times longer than 25 minutes. The correlation of nasal eosinophilia with prolongation of the nasal circulation time is statistically significant (chi square 5.84, P = .0156). We postulate that damage to the nasal mucociliary system may be an etiologic factor for a subset of patients with nonallergic rhinitis and that this damage may be mediated by eosinophils.",
}