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Detection of IgG4 and IgE Antibodies to Rubber Proteins by Immunoblotting in Latex Allergy

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Sera from four latex-allergic hospital employees (two physicians and two nurses) were examined for the occurrence of IgG4 and IgE antibodies to rubber proteins by immunoblotting. We used natural rubber sap as antigen source and detected IgG4 antibodies in all four patient sera. The IgG4 antibodies bound to 12 rubber protein antigens with molecular weights ranging from 14 kD to 53 kD. IgE antibodies bound nine of the antigens and the major antigen for both IgG4 and IgE seemed to be a 21 kD rubber protein. The parallel occurrence of IgG4 and IgE antibodies against the same rubber protein antigens suggests that IgG4 antibodies also may play a role in the pathogenesis of latex allergy.

Document Type: Research Article


Publication date: March 1, 1992

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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