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Allergic Fungal Sinusitis

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Allergic fungal sinusitis (AFS) is a noninvasive disease first described as a distinctive clinical and histopathologic entity more than 10 years ago. The typical patient is immunocompetent, atopic, has chronic sinusitis refractory to medical therapy, and 100% of those we have diagnosed have nasal polyps. Because of the histopathologic similarity to mucoid impaction of the bronchi seen in allergic bronchopulmonary aspergillosis, Aspergillus species were initially suspected as the causative agent. Subsequent reports include a number of non-Aspergillus-related cases. Both we and others have found a 7% incidence of AFS among chronic sinusitis patients requiring surgery. Relapse after surgical debridement and aeration is common and often responds to systemic corticosteroids. The diagnosis of AFS should be considered in all atopic patients with nasal polyps and chronic sinusitis. The clinical and histopathologic features of this disorder are reviewed.
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Document Type: Research Article

Publication date: 1992-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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