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Cord Blood T-Cell Determination: A Further Useful Parameter for Atopy Screening of the Newborn?

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Abstract:

In a prospective study, the total CB IgE and T-cell subpopulations in cord blood of 200 newborn children were determined by means of monoclonal antibodies (CD3, CD4, and CD8). There is no correlation between raised cord blood IgE and reduced T-cell ratio in the cord blood or with a positive family history. In a follow-up study carried out at the age of 12 to 14 months. 21% of atopic children had a positive family history and, simultaneously, a reduced total cord blood T-cell rate (CD3). Only 3% of nonatopic children had a positive family history and a reduced cord blood CD3 ratio. Statistically speaking, this distinction is significant (p < 0.01).

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854191778879421

Publication date: May 1, 1991

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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