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Pharmacological Modulation of Asthma in Relation to Mechanisms

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Asthma is a disorder of airway function that affects persons of all ages. Clinically it manifests as intermittent wheeze and cough in association with a measurable reduction in indexes of airway caliber such as peak expiratory flow or forced expiratory volume in 1 second (FEV1). Bronchoconstriction in asthma occurs by a combination of smooth muscle contraction, mucosal edema, and mucus hypersecretion. An additional abnormality in asthma is an increased responsiveness of the airways to a wide variety of exogenous stimuli that fluctuates in time and broadly relates to disease activity. It has long been known that the airways of patients who have died of asthma show widespread inflammation, however, the role of the inflammatory processes in day-to-day asthma has not been carefully evaluated.

Document Type: Research Article


Publication date: May 1, 1991

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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