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Successful Prevention of Local and Cutaneous Hypersensitivity Reactions to Seminal Fluid with Intravaginal Cromolyn

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Seminal fluid hypersensitivity usually is characterized by postcoital vulvovaginal itching, swelling, redness, with or without systemic signs and symptoms. Efforts to manage this condition have either met with poor patient acceptance or have not been uniformly successful. We describe a 23-year-old atopic woman with documented IgE-mediated local and cutaneous hypersensitivity to SF. Using a controlled, single-blind challenge method, pretreatment with intravaginal 4% cromalyn sodium in a water-based cream completely blocked both local and cutaneous immediate hypersensitivity reactions to SF in this highly sensitive patient. We believe this may represent an alternative and more desirable method of preventive management in such patients.

Document Type: Research Article


Publication date: March 1, 1991

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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