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Aerosol Physiology, Deposition, and Metered Dose Inhalers

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Abstract:

The percentage of the dose reaching the lungs from a pressurized metered dose inhaler (MDI) is likely to be a major determinant of the efficacy of inhaled bronchodilators and corticosteroids. Yet MDIs may deposit no drug in the lungs in patients with poor inhaler technique and no more than 20% of the dose under optimum conditions. Spacer devices can help to deposit as much drug as from a correctly used MDI (even in patients with poor technique) but are often large and bulky. More compact (and easier to use) pressurized devices and multidose dry powder inhalers will be valuable additions to the range of apparatus available for asthma therapy and prophylaxis.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854191778879601

Publication date: January 1, 1991

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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