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Why Do They Wheeze?

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The pathogenesis of asthma can be divided into clinical, physiological, and anatomical considerations. Clinical features include reversible obstruction, allergens, and other factors such as gastroesophageal reflux. Physiological considerations include bronchial hyperreacivity, neurologic abnormalities, nonadrenergic noncholinergic system (NANC), and neuropeptides. Anatomic and cellular considerations include eosinophils respiratory epithelium, mast cells/basophils, cytokines, and histamine-releasing factors (HRF), and histamine-release inhibitory factor (HRIF).

Document Type: Research Article


Publication date: 1991-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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