Drug Effects on Antigen-Induced Release of High Molecular Weight-Neutrophil Chemotactic Activity and Histamine in Nasal Secretion from Children with Allergic Rhinitis

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Abstract:

Five children with allergic rhinitis sensitive to house dust mite as documented by skin test, radioallergosorbent test, score and nasal provocation were studied. Patients were subjected to nasal challenge with 3.125, 6.25, 12.5, and 25 protein nitrogen g per disc of house dust mite antigens and nasal secretions were collected by the filter paper method. Neutrophil chemotactic activity (NCA) and histamine content of the nasal secretions were measured. NCA and histamine were released in a dose- and time-dependent manner, and no significant correlation between NCA and histamine was revealed in each subject. Pretreatment with 5.2 mg of nasal disodium cromoglycate or 0.5 g of nasal adrenaline 5 minutes before provocation totally inhibited mediator release upon nasal challenge with 12.5 g of house dust mite. A dose of 100  of nasal beclomethasone dipropionate 5 minutes before challenge neither inhibited clinical symptoms nor mediator release; 100 g × 3 times per day of nasal beclomethasone dipropionate for 3 days, however, significantly inhibited clinical symptoms and release of both NCA (p < 0.05) and histamine (p < 0.05). NCA eluted as a single peak with an estimated molecular weight of 600,000. These results suggest that high molecular weight-NCA may be involved in the pathogenesis of allergic rhinitis.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854190778879837

Publication date: September 1, 1990

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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