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Network Regulation of the Immune Response

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Abstract:

The immune network theory, elaborated by Jerne 15 years ago, has had a fundamental impact on our concepts of immune regulation. This theory depicts the immune system as a network of interacting idiotopes and anti-idiotopes. An idiotype is defined as the set of antigenic determinants, or idiotopes, present at or close to the antigen binding site of an immunoglobulin molecule which is able to elicit an immune response both at the cellular and humoral levels. These structures are encoded by immunoglobulin V-region genes and may be defined serologically. Recent observations suggest an important role of anti-idiotypic antibodies in regulation of the immune response and in the etiology of specific disease states, including allergic conditions. Additionally, considerable interest has been generated by their potential use as vaccines.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854189778935872

Publication date: 1989-11-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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