Platelet Activating Factor: Effects on Bronchomotor Tone and Bronchial Responsiveness in Human Beings
Authors: Chung, K. F.; Cuss, F. M.; Barnes, P. J.
Source: Allergy and Asthma Proceedings, Volume 10, Number 5, September-October 1989 , pp. 333-337(5)
Publisher: OceanSide Publications, Inc
Abstract:Platelet-activating factor (PAF) is a newly discovered lipid mediator of inflammation. When inhaled by normal volunteers, it induces bronchoconstriction associated with facial flushing and with a transient fall in circulating neutrophils. Of greater interest is its ability to induce prolonged increases in bronchial responsiveness to methacholine. These observations support an important role for PAF in asthama; the availability of specific PAF antagonists will allow us to test this hypothesis.
Document Type: Research Article
Publication date: September 1, 1989
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