Platelet Activating Factor: Effects on Bronchomotor Tone and Bronchial Responsiveness in Human Beings
Platelet-activating factor (PAF) is a newly discovered lipid mediator of inflammation. When inhaled by normal volunteers, it induces bronchoconstriction associated with facial flushing and with a transient fall in circulating neutrophils. Of greater interest is its ability to induce prolonged increases in bronchial responsiveness to methacholine. These observations support an important role for PAF in asthama; the availability of specific PAF antagonists will allow us to test this hypothesis.
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Document Type: Research Article
Publication date: 1989-09-01
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