Approved Methodology for Methacholine Challenge

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Abstract:

The challenge procedure detailed in this article should serve as a useful adjunct to routine pulmonary function testing for the diagnosis of asthma as well as a research tool for a wide variety of applications. Now that methacholine has been approved by the Food and Drug Administration and made available to the clinician in an appropriate form for clinical use (Provocholine, Roche), it is anticipated that the technique of methacholine challenge will become part of the armamentarium of pulmonary laboratories as well as pulmonologists and allergists who diagnose and treat asthma. The technique may be safely conducted in an outpatient setting using the standardized procedures detailed here. When properly applied in appropriate clinical circumstances, the test is a useful and sometimes necessary addition to routine history, physical examination, and pulmonary function tests conducted for the purposes of establishing the presence of hyperactive airways.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854189778959867

Publication date: September 1, 1989

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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