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Evolution of Sensitivity to Hymenoptera Venoms During Maintenance Immunotherapy

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Duration of venom immunotherapy still remains questionable since some patients lose their sensitivity. Venom immunotherapy can be stopped when venom skin tests and specific IgE are negative. Five studies have been performed to prospectively study the evolution of skin tests and specific IgE after three to six years of maintenance immunotherapy. Four studies showed that skin tests became negative in 30 to 55% of patients depending upon the venom species and the duration of the treatment. Mean specific IgE declined in most studies but were negative only in a substantial number of patients in the European studies. Adults and children had a similar rate of disappearance of skin test reactivity. In one study, skin tests were negative in ⅓ of patients after one year of treatment suggesting that venom immunotherapy may be given for a short period of time in some patients.

Document Type: Research Article


Publication date: March 1, 1989

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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