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Studies of the Natural History of Insect Sting Allergy

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The natural history of insect sting allergy was studied by observations of the results of re-sting on two groups of individuals who had prior sting anaphylaxis, had demonstrable venom-specific IgE, and did not receive venom immunotherapy. In the first study group, the mean duration between the initial sting reaction and re-sting exposure was 4.5 years; the re-sting reaction rate was 35%/sting and 50%/patient. In the second long-term study, the mean duration between the sting reaction and re-sting was 7.3 years; the re-sting reaction rate was 12%/sting and 12%/patient. Factors influencing the likelihood of re-sting reaction included older age, and the occurrence of cardiovascular/respiratory anaphylactic symptoms.

In a prospective and retrospective study of 133 patients with large local reactions, re-sting observations indicated an extremely high recurrence of similar large local reactions, with little risk of subsequent anaphylaxis.

These data suggest that: (1) insect sting anaphylaxis is a self-limiting process for the majority of individuals, and (2) re-stings in individuals who have had large local reactions have a relatively benign prognosis.

Document Type: Research Article


Publication date: March 1, 1989

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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