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Complexities of Establishing an Early Diagnosis of Allergic Bronchopulmonary Aspergillosis in Children

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The problem of attempting to diagnose allergic bronchopulmonary aspergillosis (ABPA) in children at an early age, prior to the development of undesirable sequelae, such as bronchiectasis, is reviewed. Two cases of ABPA with onset under the age of ten are presented as illustrations of the complexities of securing an early diagnosis of ABPA. ABPA is not infrequent in children, with children under ten representing an estimated 9% to 10% of patients with the disorder. A high index of suspicion and persistence are important in establishing the diagnosis. ABPA may be identified in patients with detectable central bronchiectasis (ABPA-CB) or in patients seropositive (ABPA-S) who do not yet have bronchiectasis. Some complexities in making an early diagnosis of ABPA include: 1) insensitivity of CT scans in detecting central bronchiectasis, 2) lack of current chest radiographic infiltrates, 3) lack of peripheral blood eosinophilia and precipitins to A. fumigatus and 4) weakly reactive immediate skin test to Aspergillus.
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Document Type: Research Article

Publication date: 1989-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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