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Oral Challenges to Detect Aspirin and Sulfite Sensitivity in Asthma

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Oral challenge with aspirin, or potential cross-reacting substances, is an effective method for establishing the presence of these sensitivities in asthmatic subjects. However, in patients with concomitant active irritable airways, testing is inaccurate and potentially dangerous. Strategies for dealing with these problems and other details important in conducting oral challenges are outlined.

Sulfite challenges are conducted in a different manner and there has not been cross-sensitivity established between sulfite sensitive and aspirin sensitive asthmatics. However, many of the same problems created by heightened airway activity interfere with the accuracy of sulfite challenges. A special obstacle in interpreting the results of sulfite challenges is the issue of specificity. Oral challenges with solutions of sulfite improve sensitivity of the challenge procedure. But only low dose sulfite solutions (50 mg/ml or less) and capsules of sulfite salts are specific provoking substances for sulfite sensitivity.

Document Type: Research Article


Publication date: March 1, 1988

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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