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Laboratory Tests for Total and Allergen-specific Immunoglobulin E

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The principles of measurement of IgE by enzyme-immunoassay are given. A Bayesian approach is taken for the clinical interpretation of serum total IgE. Application of Bayes' Theorem to serum total IgE can significantly influence the probability of a clinical diagnosis of allergy.

There is a correlation between allergen-specific IgE measured by enzyme-immunoassay, by radioallergosorbent test and by skin tests for immediate hypersensitivity. However, there is a need to standardize the reagents used for allergy skin testing, as well as the reagents and methods used for the laboratory measurement of allergen-specific IgE.

Document Type: Research Article


Publication date: March 1, 1988

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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