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IgG4 Immunodeficiency

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IgG4 deficiency can be an isolated phenomenon, or it can occur in combination with deficiencies of IgG2, IgA, and/or IgG1 (in order of decreasing frequency). Isolated deficiency of IgG4 is associated with symptoms and signs which are similar to those associated with other IgG sub class deficiencies. The most common manifestation is unusual frequency of pyogenic infections, most often of the respiratory tract. There is also an increased frequency of isolated serum IgG4 deficiency in subjects who have recurrent or chronic diarrhea, asthma, adverse reactions to foods, chronic candidiasis, pediatric AIDS, and autoimmune disorders. The mean and normal ranges of serum IgG4 in 400 subjects ages four months to 17 years are given. Diagnostic studies, unique features of IgG4, illustrative case reports and possible mechanisms are discussed.

Document Type: Research Article


Publication date: January 1, 1988

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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