The Role of Antiglobulins in IgG4-Mediated Allergic Diseases
Although IgG4 (or at least one of its variants) does have receptors on basophils, this IgG subclass apparently cannot mediate an allergen-triggered release of mediators. Evidence is now available to suggest that IgG4-bearing basophils can be "fired off" to release histamine with an IgM anti-IgG which is frequently found in atopic patients. If an autoimmune process of the kind described here can contribute to the pathological changes in atopic disorder, then a whole new approach to the diagnosis and treatment of allergic disease must be considered.
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Document Type: Research Article
Publication date: 1988-01-01
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- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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