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Immunochemical Characteristics of IgG4 Antibodies

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Abstract:

Although a small part of the IgG4 subclass probably can bind to basophils (and mast cells), IgG4 antibodies usually do not behave as anaphylactic antibodies. Therefore, detection of IgG4 antibodies in serum is not a suitable in vitro assay for IgG-S-TS activity.

Furthermore, differences between IgG4 and the other IgG subclasses with respect to antibody valency and interaction with the complement system, stress the point that IgG4 takes a special place in the humoral immune response.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854188778984554

Publication date: 1988-01-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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