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IgG Subclass Antibodies in Response to House Dust Mite Immunotherapy

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The data obtained so far indicate that house dust mite immunotherapy stimulates an IgG antibody response that is predominantly of IgG4 subclass. Early in the course, however, a rise in IgG1 antibodies can be detected, but as treatment goes on IgG4 becomes more prominent. The association between the development of IgG4 antibodies and objectively measured clinical improvements resulting from immunotherapy, strongly suggests that IgG4 antibodies might exert a blocking effect on IgE-mediated immediate hypersensitivity.

Document Type: Research Article


Publication date: November 1, 1987

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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