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Allergen Specific IgG Subclass Antibody Response in Hyposensitization with Dermatophagoides Pteronyssinus Extract

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Abstract:

Most of the controlled trials of specific immunotherapy (SIT) with house dust mite showed a good clinical efficacy of different kinds of extract after variable periods of treatment. However, few of them looked at all the parameters available to monitor this therapy, such as threshold dose of specific provocation test, end point titration and immunological variations.

In particular, the behaviour of specific IgE antibodies is not completely known, while, in more recent studies, mite specific IgG antibodies have been shown to increase even in the early stages of treatment.

Few data are available on mite specific IgG1–yy4 subclasses.

The preliminary results of a double blind placebo controlled trial we performed with alginate conjugated Dermatophagoides pteronyssinus extract seem to indicate a good clinical and immunological response to this kind of extract.

Moreover, we observed a significant increase of specific IgG antibodies, total and subclasses IgG1,2,4, with a prevalence of IgG4 subclass after three months of SIT.

After two years of SIT mite specific IgG1 antibodies showed a tendency to decrease, while IgG4 antibodies maintained a constantly high level.

These data suggest a restriction of IgG response to IgG4 subclass after prolonged mite specific immunotherapy, confirming previous similar results obtained in subjects with long lasting honey bee venom exposure.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854187778999630

Publication date: November 1, 1987

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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