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IgG4 and Hyposensitization

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The mechanism of action of hyposensitization is still unclear. Probably, allergen-blocking antibodies have some effect, in particular in insect venom allergy, but it is likely that other mechanisms are operative as well. With the types of treatment currently available suppression of the production of specific IgE antibodies does not seem to be a dominating factor. In view of the presumed minor contribution of allergen-blocking antibodies in inhalant allergy, it is as yet impossible to define the role of IgG4 antibodies other than quantitatively: It is the main allergen-blocking antibody! There is no conclusive evidence that the IgG4 is the exclusive allergen-blocking antibody in immediate type allergy. However, its main biologic significance might well be on a completely different level, viz. prevention of immune complex disease. The production of non-complement fixing antibodies, unable to form large complexes due to functional monovalency, during prolonged antigenic exposure seems to provide adequate protection against complement-induced damage and other sequela of precipitating immune complexes that can be expected from a persistent production of IgG1. The rare occurrence of immune complex induced disorders during hyposensitization therapy is possibly a result of this phenomenon.
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Document Type: Research Article

Publication date: 1987-11-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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