The Molecular Pathology of IgG4 in Allergic Conditions

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In the time available, I have built up a picture of the molecular pathology of IgE antibodies; and considered that of IgG4 antibodies in comparison. As will have become apparent, much less direct evidence is available on the latter; partly because of the lack of reliable and relevant in vitro functional assays. Nevertheless, I hope that in speculating on the possible molecular pathology of IgG4 antibodies, I have said enough to convince you that their likely mode of action in immediate-type hypersensitivity reactions will prove to be fundamentally different to that of IgE antibodies. It is important to bear this in mind in attempts to devise suitable assays of use in clinical diagnosis; and in considering their unique contributions to allergic reactions.

Document Type: Research Article


Publication date: November 1, 1987

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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