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Histamine Receptors in the Lung

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The availability of specific histamine receptor antagonists has provided evidence that human airways have both H1 and H2 receptors. H1 receptors, which mediate bronchoconstriction, predominate. H1 receptor antagonism can produce significant bronchodilatation in some asthmatics, block bronchoconstriction induced by antigen and histamine inhalation challenge, and have some protective effect against exercise and aspirin-induced bronchoconstriction. H1 receptors mediate bronchodilatation, but this effect is relatively weak in man.

The role of classic antihistamines (H1 receptor antagonists) in the treatment of asthma has not been established. Since factors that precipitate asthma are quite varied, these agents may provide benefit in select patients. The availability of new, nonsedating H1 receptor antagonists show some promise in this regard. Future studies may more precisely define their use in asthma therapy.

Document Type: Research Article


Publication date: March 1, 1987

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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