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Corticosteroids and Theophylline Clearance

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Whether the administration of corticosteroids affects the disposition of theophylline remains unclear. Increased clearance, decreased clearance, and no change in clearance are all reported with steroid doses that are used in the treatment of asthma. This study found that theophylline kinetics among two normal subjects did not change after corticosteroids, while in one normal adult, clearance was significantly higher after corticosteroids. Additional study will be needed to ascertain if oral corticosteroids given over a short period may affect theophylline disposition in some patients.

Document Type: Research Article


Publication date: March 1, 1987

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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