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Glucocorticoid-induced Enhancement of IgE Synthesis

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Glucocorticoid-induced enhancement of polyclonal immunoglobulin production of the IgG, A, and M classes by human peripheral blood mononuclear cells has been shown to be dependent on regulatory T-cells. The following in vitro investigation demonstrated an enhancing effect of glucocorticoid on IgE production by mononuclear cells from atopic patients, but not by cells from non-atopic subjects. Augmentation was noted even in cell populations depleted of T cells and monocytes. These observations suggest that the corticosteroid acted directly on an IgE B cell at a late stage of differentiation that was no longer dependent on helper T-cells, although an additional effect on T-suppressor cells was not excluded.
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Document Type: Research Article

Publication date: 1987-03-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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