The Role of Kinins in Human Allergic Disease

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Abstract:

We have provided clear evidence that kinins are generated during local allergic reactions in man and have begun studies on the mechanisms by which kinins are formed during these reactions. Clearly, the extent to which kinins may contribute to the symptomatology of allergic rhinitis remains to be determined, but the levels of kinins detected in the model systems described above are sufficient to cause relatively profound physiologic effects. In addition to its ability to produce vasodilatation and edema, bradykinin has been reported to stimulate fluid production from airway submucosal glands via a reflex action and could function to increase mucus production and cause rhinorrhea. Kinins have also been shown to increase chloride transport in the airway and to stimulate the production of prostaglandin E2 by epithelial cells. Thus we believe kinins must now be considered as potentially important mediators in the pathogenesis of human allergic diseases.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854186778995257

Publication date: May 1, 1986

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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