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Response of Human Airways to Inhaled Chemicals

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Abstract:

A variety of complex pulmonary immunologic responses may follow the inhalation of reactive chemical haptens. Trimellitic anhydride (TMA) is an industrial chemical used as a plasticizer (and serves as a model of occupational immunologic lung disease). Sensitization to TMA can take several forms — IgE-mediated asthma and rhinitis, a late reaction in the lung which resembles hypersensitivity pneumonitis and an irritated airway syndrome. Antibody studies show that TMA can combine with bodily constituents to form new antigenic determinants (NADs) which are probably the most immunogenic form of the compound.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854185779045008

Publication date: 1985-06-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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