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The Treatment of Asthma — Beyond Bronchodilators

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Abstract:

I have attempted to indicate the importance of Ca2+ ions in the various pathogenetic processes that contribute to the development of asthma and to show how both Ca2+ entry blockers and calmodulin-active compounds may alter the function of mediator releasing cells and smooth muscle contractility in vitro as well as their effects in various experimental animal situations and on airway function in man. It would appear that the current available cardiovascular-active Ca2+ entry blockers are not very specific with regard to either airway smooth muscle or mast cell function but their observed activities certainly warrant the search for new Ca2+ antagonists that might have greater specificity for airway smooth muscle, for example, and might facilitate therapy of asthma. There have been remarkably few studies of the effects of calmodulin-active compounds on allergic processes or in asthma. The activity of these compounds in various experimental models demands that they should be further studied with respect to their possible clinical usefulness in the management of asthma and other allergic disorders.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854185779045035

Publication date: June 1, 1985

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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