Advances in the Diagnosis and Management of Penicillin Allergy

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IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem. Advances in our understanding of the immunochemistry of penicillin allergy have improved our ability to predict and to avoid these reactions. Immunodiagnostic techniques can identify patients at risk for anaphylaxis to -lactam antibiotics with a high degree of precision. Clinical and immunologic studies have demonstrated that penicillin allergic subjects may have allergic reactions to cephalosporins although the absolute frequency of clinical cross-reactions is not clear. If -lactam drugs are needed for treatment of penicillin allergic patients, acute desensitization appears to be an acceptably safe procedure for avoiding anaphylaxis.

Document Type: Research Article


Publication date: March 1, 1985

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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