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Histamine Release in Anesthesia and Surgery

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Abstract:

Histamine release can occur in response to anaphylactic or chemically mediated anaphylactoid reactions during general anesthesia. Narcotics and muscle relaxants have been demonstrated both in vitro and in vivo to cause significant histamine release. This histamine release appears to be directly related to changes in the cardiovascular system that are often seen during anesthesia. The use of combined H1 and H2 antagonists to attenuate the effects of anaphylactoid reactions in humans has been shown in several controlled trials. In addition, recent experience with chymopapain administration suggests that the use of H1 and H2 antagonists may be useful in the prophylaxis of immunologically mediated reactions.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854185779048924

Publication date: December 1, 1985

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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