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Histamine Receptors In The Heart

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Cardiac manifestations of systemic anaphylaxis range from transient electrocardiographic changes to ventricular fibrillation with complete circulatory collapse. Many of these cardiovascular events are attributable to the stimulation of cardiac H1- and H2- receptors by histamine released during anaphylaxis. Indeed, the heart itself has been shown to contain high concentrations of histamine, which can be released not only by IgE-mediated hypersensitivity reactions, but by various drugs and chemicals as well. Release of cardiac histamine is accompanied by changes in rate, rhythm, contractility, and electrical conduction which can be reproduced by the administration of exogenous histamine. H2-receptors have been shown to mediate histamine-induced increases in sinus rate, myocardial contractility, and electrical automaticity, while decreases in contractility and atrioventricular conduction velocity are H1-mediated.

Document Type: Research Article


Affiliations: Department of Pharmacology, Cornell University Medical College, New York, New York 10021

Publication date: September 1, 1984

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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