Histamine Receptors In The Heart
Cardiac manifestations of systemic anaphylaxis range from transient electrocardiographic changes to ventricular fibrillation with complete circulatory collapse. Many of these cardiovascular events are attributable to the stimulation of cardiac H1- and H2- receptors by histamine released during anaphylaxis. Indeed, the heart itself has been shown to contain high concentrations of histamine, which can be released not only by IgE-mediated hypersensitivity reactions, but by various drugs and chemicals as well. Release of cardiac histamine is accompanied by changes in rate, rhythm, contractility, and electrical conduction which can be reproduced by the administration of exogenous histamine. H2-receptors have been shown to mediate histamine-induced increases in sinus rate, myocardial contractility, and electrical automaticity, while decreases in contractility and atrioventricular conduction velocity are H1-mediated.
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Document Type: Research Article
Affiliations: Department of Pharmacology, Cornell University Medical College, New York, New York 10021
Publication date: 1984-09-01
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