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Anaphylaxis is an acute medical emergency caused by systemic mast cell degranulation in response to diverse stimuli. The etiology of anaphylaxis ranges from IgE-mediated allergic reactions to anaphylactoid responses caused by infusions of radiocontrast media. The common thread in the spectrum of causes is mast cell degranulation with systemic release of mediators, particulary histamine. As histamine is one of the predominant causes of the clinical changes occurring in anaphylaxis, treatment of anaphylaxis requires both H1 and H2 histamine receptor antagonists in addition to epinephrine.

Document Type: Research Article


Affiliations: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C205, Bethesda, Maryland 20205

Publication date: September 1, 1984

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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