Abstract:Anaphylaxis is an acute medical emergency caused by systemic mast cell degranulation in response to diverse stimuli. The etiology of anaphylaxis ranges from IgE-mediated allergic reactions to anaphylactoid responses caused by infusions of radiocontrast media. The common thread in the spectrum of causes is mast cell degranulation with systemic release of mediators, particulary histamine. As histamine is one of the predominant causes of the clinical changes occurring in anaphylaxis, treatment of anaphylaxis requires both H1 and H2 histamine receptor antagonists in addition to epinephrine.
Document Type: Research Article
Affiliations: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C205, Bethesda, Maryland 20205
Publication date: 1984-09-01
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