Abnormalities in the Histamine-Induced Suppressor Cell Network in Atopic Subjects

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Abstract:

Antibody responses of the IgE isotype, like other immunoglobulin classes, are regulated by a finely-tuned network of complex positive and negative regulatory factors. This paper reviews studies concerning abnormalities of histamine-induced suppressor T cell activity in atopic subjects. In atopic subjects, there is a reduction in the generation of histamine-induced suppressor cell activity which positively correlates with decreased phenotypic expression of histamine-type 2 receptors on T lymphocytes. Nonatopic control subjects with systemic mastocytosis have normal functional and phenotypic data, suggesting that chronic in vivo activation by histamine of T cells from atopies does not explain the abnormal histamine-induced suppressor response. Proper functioning of the histamine-induced suppressor cell system involves obligatory interactions between lymphocytes and monocytes. Monocytes from atopic subjects produced significantly less prostaglandin E2 in response to exogenous histamine-induced suppressor factor. A new immunostimulatory drug, Fanetizole mesylate, partially corrects the abnormal histamine-induced suppressor response. Clinical application of this information may lead to new treatments of the atopic diathesis.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854184779070227

Affiliations: Pulmonary Center, Evans Memorial Department of Clinical Research, Boston University School of Medicine, Boston, MA

Publication date: September 1, 1984

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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