Histamine H1 and H2 Receptors
Abstract:Histamine, one of the major mediators of immediate hypersensitivity (allergic) reactions, is capable of eliciting a variety of physiologic responses (Table 2) of major clinical importance. The mediation of histamine's actions occurs as a consequence of the generation of either cyclic GMP or cyclic AMP subsequent to the stimulation of specific H1 or H2 receptors, respectively. The development of specific histamine receptor agonists and antagonists (Table 1) and radioligand binding techniques should prove useful in the elucidation of the precise sequence of events following histamine receptor interactions. In addition, knowledge of histamine receptor subtypes and histamine-induced post-receptor events have proven beneficial in the development of treatment modalities for diseases such as anaphylaxis and the Zollinger-Ellison syndrome.
Document Type: Research Article
Affiliations: Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205
Publication date: September 1, 1984
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